Parham-Type Cycliacylation with Weinreb Amides. Application to the Synthesis of Fused Indolizinone Systems

J Ruiz, N Sotomayor, E Lete

Index: Ruiz, Javier; Sotomayor, Nuria; Lete, Esther Organic Letters, 2003 , vol. 5, # 7 p. 1115 - 1117

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Citation Number: 40

Abstract

Weinreb amides behave as efficient internal electrophiles in Parham-type cycliacylation reactions. Thus, aryl-and heteroaryllithiums generated by lithium-halogen exchange undergo intramolecular cyclization to give fused indolizinone systems as pyrrolo [1, 2-b] isoquinolines, thieno [2, 3-f] indolizinones, and pyrrolo [1, 2-b] acridinones in high yields.