The 2-(diphenylphosphino) ethyl group (DPPE) as a new carboxyl-protecting group in peptide chemistry
D Chantreux, JP Gamet, R Jacquier, J Verducci
Index: Chantreux, Dominique; Gamet, Jean-Paul; Jacquier, Robert; Verducci, Jean Tetrahedron, 1984 , vol. 40, # 16 p. 3087 - 3094
Full Text: HTML
Citation Number: 18
Abstract
The use of the 2-(diphenylphosphino) ethyl group for carboxyl-protection of amino acids or peptides is described. This group is easily introduced by esterification using 2- (diphenylphosphino) ethanol in the presence of dicyclohexylcarbodiimide and 4- (dimethylamino) pyridine. These Dppe esters are stable under the standard conditions for peptide synthesis. Deprotection is carried out under mild conditions by quaternisation ...
Related Articles:
The synthesis of (-)-sirenin. sperm attractant of the water mold allomycesmacrogynus
[Kitahara, Takeshi; Horiguchi, Akira; Mori, Kenji Tetrahedron, 1988 , vol. 44, # 15 p. 4713 - 4720]
Micellar effects on competitive hydrolysis and hydration of vinyl phosphonium salts
[Journal of Organic Chemistry, , vol. 51, # 8 p. 1350 - 1352]