Helvetica Chimica Acta

β??Lactams from D??Erythrose??Derived Imines: A Convenient Synthesis of 2, 3??Diamino??2, 3??dideoxy??D??mannonic??Acid Derivatives

T Storz, B Bernet, A Vasella

Index: Storz, Thomas; Bernet, Bruno; Vasella, Andrea Helvetica Chimica Acta, 1999 , vol. 82, # 12 p. 2380 - 2412

Full Text: HTML

Citation Number: 13

Abstract

Abstract The D-manno-configured N-anisylated β-lactam 40, the β-lactam carboxylic acids 4 and 43, and the corresponding phosphonic-acid isosters 49 and 50 have been synthesized from D-glucose in 8–10 steps, respectively. None of these compounds exhibited a significant inhibitory activity in vitro against the sialidases of Vibrio cholerae, Salmonella typhimurium, Influenza A (N9), and Influenza B virus. Cycloaddition of the in situ generated imines ...