Tricyclic analogues of the antiallergic agent oxatomide: 1-(3-(4-(10, 11-Dihydro-5H-dibenzo [a, d] cycloheptene-5-yl)-1-piperazinyl) propyl)-1, 3-dihydro-2H- …

J Jílek, J Holubek, E Svátek, J Metyš…

Index: Jilek, Jiri; Holubek, Jiri; Svatek, Emil; Metys, Jan; Frycova, Hana; et al. Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 4 p. 870 - 883

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Citation Number: 9

Abstract

Abstract 11-Chloro-6, 11-dihydrodibenzo [b, e] thiepin and its 2-methyl derivative VI were transformed via the 11-(4-ethoxycarbonyl)-1-piperazinyl) compounds IVc and Vc to 11-(1- piperazinyl) compounds IVb and Vb. Their reactions with 1-(3-chloropropyl)-1, 3-dihydro-2H- benzimidazol-2-one (II) afforded the title compounds IVa and IVb. Similar reactions and sequences in the series of 10, 11-dihydro-5H-dibenzo [a, d] cycloheptene, 4, 9- ...