Toxicology Letters 2013-06-07

Aberrant activation of M phase proteins by cell proliferation-evoking carcinogens after 28-day administration in rats

Atsunori Yafune, Eriko Taniai, Reiko Morita, Hitomi Hayashi, Kazuhiko Suzuki, Kunitoshi Mitsumori, Makoto Shibutani

Index: Toxicol. Lett. 219(3) , 203-10, (2013)

Full Text: HTML

Abstract

• This study aimed to identify early prediction markers of carcinogens in rats. • Cellular distribution of cell cycle proteins was analyzed after 28-day treatment. • Cell proliferation-evoking carcinogens induced activation of M phase proteins. • Carcinogens lacking proliferative activity did not have these effects. • Cell proliferation and M phase proteins might functions as an early prediction unit.

Related Compounds

Related Articles:

Phenethyl isothiocyanate, a naturally occurring phytochemical, is an antagonist of the aryl hydrocarbon receptor.

2012-03-01

[Mol. Nutr. Food. Res. 56(3) , 425-34, (2012)]

Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

2008-06-12

[J. Med. Chem. 51 , 3275-87, (2008)]

In vitro metabolic conversion of the organic breakdown products of glucosinolate to goitrogenic thiocyanate anion.

2015-08-30

[J. Sci. Food Agric. 95 , 2244-51, (2015)]

ID helix-loop-helix proteins as determinants of cell survival in B-cell chronic lymphocytic leukemia cells in vitro.

2015-01-01

[Mol. Cancer 14 , 30, (2015)]

Glutathionyl-hydroquinone reductases from poplar are plastidial proteins that deglutathionylate both reduced and oxidized glutathionylated quinones.

2015-01-02

[FEBS Lett. 589(1) , 37-44, (2014)]

More Articles...