Structural and kinetic isotope effect studies of nicotinamidase (Pnc1) from Saccharomyces cerevisiae
…, MA Anderson, KA Hoadley, JL Keck, WW Cleland…
Index: Smith, Brian C.; Anderson, Mark A.; Hoadley, Kelly A.; Keck, James L.; Cleland, W. Wallace; Denu, John M. Biochemistry, 2012 , vol. 51, # 1 p. 243 - 256
Full Text: HTML
Citation Number: 5
Abstract
Nicotinamidases catalyze the hydrolysis of nicotinamide to nicotinic acid and ammonia. Nicotinamidases are absent in mammals but function in NAD+ salvage in many bacteria, yeast, plants, protozoa, and metazoans. We have performed structural and kinetic investigations of the nicotinamidase from Saccharomyces cerevisiae (Pnc1). Steady-state product inhibitor analysis revealed an irreversible reaction in which ammonia is the first ...
Related Articles:
[Ingleson, Michael J.; Barrio, Jorge Perez; Bacsa, John; Steiner, Alexander; Darling, George R.; Jones, James T. A.; Khimyak, Yaroslav Z.; Rosseinsky, Matthew J. Angewandte Chemie - International Edition, 2009 , vol. 48, # 11 p. 2012 - 2016]
[Jing, Fangli; Zhang, Yuanyuan; Luo, Shizhong; Chu, Wei; Zhang, Hui; Shi, Xinyu Journal of Chemical Sciences, 2010 , vol. 122, # 4 p. 621 - 630]
[Venugopal, Akula; Sarkari, Reema; Anjaneyulu, Chatla; Krishna, Vankudoth; Kumar, Mandari Kotesh; Narender, Nama; Padmasri, Aytam Hari Applied Catalysis A: General, 2014 , vol. 469, p. 398 - 409]
Formation of pyrazines in Maillard model systems of lysine-containing dipeptides
[Van Lancker, Fien; Adams; De Kimpe, Norbert Journal of Agricultural and Food Chemistry, 2010 , vol. 58, # 4 p. 2470 - 2478]
Formation of pyrazines in Maillard model systems of lysine-containing dipeptides
[Van Lancker, Fien; Adams; De Kimpe, Norbert Journal of Agricultural and Food Chemistry, 2010 , vol. 58, # 4 p. 2470 - 2478]