Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus

…, A Carella, L Gabryelski, L Jin, JH Lin, E Emini…

Index: Lu, Zhijian; Raghavan, Subharekha; Bohn, Joann; Charest, Mark; Stahlhut, Mark W.; Rutkowski, Carrie A.; Simcoe, Amy L.; Olsen, David B.; Schleif, William A.; Carella, Anthony; Gabryelski, Lori; Jin, Lixia; Lin, Jiunn H.; Emini, Emilio; Chapman, Kevin; Tata, James R. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 10 p. 1821 - 1824

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Citation Number: 15

Abstract

A series of highly potent HIV protease inhibitors have been designed and synthesized. These compounds are active against various clinical viral isolates as well as wild-type virus. The synthesis and biological activity of these HIV protease inhibitors are discussed. ... A series of highly potent HIV protease inhibitors have been designed and synthesized. These compounds are active against various clinical viral isolates as well as wild-type virus. The synthesis and biological ...

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