(Fluoren-9-ylmethoxy) carbonyl (Fmoc) amino acid chlorides. Synthesis, characterization, and application to the rapid synthesis of short peptide segments

…, SY Sadat-Aalaee, JH Tien, DC Langridge

Index: Carpino, Louis A.; Cohen, Beri J.; Stephens, Kenton E.; Sadat-Aalaee, S. Yahya; Tien, Jien-Heh; Langridge, Denton C. Journal of Organic Chemistry, 1986 , vol. 51, # 19 p. 3732 - 3734

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Citation Number: 222

Abstract

Sir: Although protected amino acid chlorides have been known as coupling agents since the earliest days of peptide synthesis, they have never been widely used except in special circumstances.' Protecting groups stable enough to survive conversion to an acid chloride are generally difficult to deblock. We point out that with the develop- ment of the Fmoc amino-protecting group,6 there is no longer a need to avoid the use of acid chlorides. Under appropriate ...