Synthesis of aryl sulfonamides via palladium-catalyzed chlorosulfonylation of arylboronic acids

…, N Niljianskul, SL Buchwald

Index: Debergh, J. Robb; Niljianskul, Nootaree; Buchwald, Stephen L. Journal of the American Chemical Society, 2013 , vol. 135, # 29 p. 10638 - 10641

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Citation Number: 30

Abstract

In principle, a transition metal catalyst could obviate the need for such reagents and permit the convergent synthesis of sulfonamide analogues, allowing variation of both sulfonyl (−SO 2 −) substituents. Unfortunately, success in this area of catalysis is limited to a single Pd-catalyzed aminosulfonylation process, initially reported by Willis in 2010, to prepare N-amino-sulfonamides (1) from aryl iodides and hydrazines (eq 1).(12) While this example represents an ...