Isoxazolylpyrrolidinylpiperazine Ligands, a New Class for Dopamine D 3 and D 4 Receptor Antagonists

YN Oh, J Kwak, HY Koh, SH Jung

Index: Oh, Yoo Na; Kwak, Jumyung; Koh, Hun Yeong; Jung, Sun Ho Bulletin of the Korean Chemical Society, 2012 , vol. 33, # 12 p. 4227 - 4230

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Abstract

Since the dopamine receptor system plays an important role in the development of neurological disorders like schizophrenia, 1-5 extensive efforts have been made to explore potent and selective ligands for dopamine receptors for the discovery of antipsychotic drugs. 6-10 In connection with search for potent ligands for dopamine receptors, we have studied the construction and biological activities of libraries of arylpiperazine derivatives with ...