Steroids

Phenylalanine 93 of the human UGT1A10 plays a major role in the interactions of the enzyme with estrogens

C Höglund, N Sneitz, A Radominska-Pandya…

Index: Steroids, , vol. 76, # 13 p. 1465 - 1473

Full Text: HTML

Citation Number: 10

Abstract

... this site in more detail, using site directed mutagenesis, activity analyses of steroids, coumarins and ... in duplicates (at most 15% difference between duplicates), in a final volume of 100 μl. ... in the F93A mutant and, strikingly, very high activity toward this synthetic steroid by F93G ...

Related Articles:

Development of a rapid and detailed structural identification system with an on-line immobilized enzyme reactor integrated into LC-NMR

[Chemical and Pharmaceutical Bulletin, , vol. 58, # 3 p. 423 - 425]

Accurate prediction of glucuronidation of structurally diverse phenolics by human UGT1A9 using combined experimental and in silico approaches

[Pharmaceutical Research, , vol. 29, # 6 p. 1544 - 1561]

More Articles...