Concentrations of very long-chain fatty acid in whole blood are associated with cardiovascular risk factors in children.

Aya Okahashi, Tomoo Okada, Emiko Saito, Michio Miyashita, Yuki Kuromori, Fujihiko Iwata, Mitsuhiko Hara, Hideo Mugishima, Yohei Kitamura, Takashi Shimizu, Aya Okahashi, Tomoo Okada, Emiko Saito, Michio Miyashita, Yuki Kuromori, Fujihiko Iwata, Mitsuhiko Hara, Hideo Mugishima, Yohei Kitamura, Takashi Shimizu

Index: Clin. Chim. Acta 401(1-2) , 141-3, (2009)

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Abstract

Fatty acid metabolism has a close relationship with metabolic syndrome. Saturated very long-chain fatty acid (hexacosanoic acid; C26:0) was recently reported to be associated with cardiovascular risk factors in adults.Eighty-eight children (47 male, 41 female; average age, 10.9 y) participated in this study. Concentrations of C26:0 in whole blood were measured.Compared with reported concentrations in the whole blood of adults, children had lower C26:0 concentrations, which had a close relationship with abdominal obesity, increased concentrations of low-density lipoprotein cholesterol and high blood pressure. C26:0 concentrations increased with increasing number of risk factors.Elevation of C26:0 concentrations may be one of the metabolic features of children with cardiovascular risk factors.