Reproductive Toxicology 2012-07-01

Toxicological evaluation of ammonium perfluorobutyrate in rats: Twenty-eight-day and ninety-day oral gavage studies

John L. Butenhoff, James A. Bjork, Shu-Ching Chang, David J. Ehresman, George A. Parker, Kaberi Das, Christopher Lau, Paul H. Lieder, François M. van Otterdijk, Kendall B. Wallace, John L Butenhoff, James A Bjork, Shu-Ching Chang, David J Ehresman, George A Parker, Kaberi Das, Christopher Lau, Paul H Lieder, François M van Otterdijk, Kendall B Wallace

Index: Reprod. Toxicol. 33(4) , 513-30, (2012)

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Abstract

Highlights ► The effects of perfluorobutyrate were studied in 28-day and 90-day studies in rats. ► No effects were observed in female rats given up to 150mg/kg perfluorobutyrate. ► Male effects included reversible hepatocellular hypertrophy and hypolipidemia. ► Effects observed were consistent with hepatic activation of PPARα and CAR. ► NOAEL for male rats was 6mg/kg in both the 28-day and 90-day studies.

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