Logic networks based on immunorecognition processes.

Guinevere Strack, Soujanya Chinnapareddy, Dmytro Volkov, Jan Halámek, Marcos Pita, Igor Sokolov, Evgeny Katz

Index: J. Phys. Chem. B 113 , 12154-12159, (2009)

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Abstract

The biochemical system logically processing biochemical signals using immune-specific and biocatalytic reactions was designed, and the generated output signals were analyzed by AFM and optical means. Different patterns of immune signals resulted in the formation of various interfacial structures followed by biocatalytic reactions activated by the next set of biochemical inputs. The developed approach to multisignal biosensing allows qualitative evaluation of the biochemical information in terms of YES-NO, providing the base for novel molecular-level logic analysis of complex patterns of biochemical signals. Application of AFM to read out the structures generated on the interface could potentially lead to substantial miniaturization of the immune logic systems.