Asymmetric Palladium (II)??Catalyzed Cascade Reaction Giving Quaternary Amino Succinimides by 1, 4??Addition and a Nef??Type Reaction

M Weber, W Frey, R Peters

Index: Weber, Manuel; Frey, Wolfgang; Peters, Rene Angewandte Chemie - International Edition, 2013 , vol. 52, # 50 p. 13223 - 13227

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Citation Number: 26

Abstract

Chiral succinimides play a vital role in pharmaceutical sciences.[1] They are typically synthesized by 1, 4-additions to maleimides.[1] The pharmacologically important class of quaternary a-amino succinimides—formal derivatives of aalkyl aspartic acid [2]—has received particular attention from both academic and industrial laboratories for its benefit for application in drug design (Figure 1). For instance, introduction of succinimides 1 in ...