Synthetic pyrethroid increases lipid and protein oxidation and induces glutathione depletion in the cerebellum of adult rats: ameliorative effect of vitamin C.

Hamadi Fetoui, Radhouane Gdoura

Index: Hum. Exp. Toxicol. 31(11) , 1151-60, (2012)

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Abstract

The wide use and wide-spectrum toxicity of synthetic pyrethroid (SP) insecticides make them an emerging ecotoxicological concern. The objective of the current study was aimed to investigate the involvement of oxidative stress in lambda-cyhalothrin (LTC)-induced cerebellum damages in adult rats and to evaluate the possible protective effect of vitamin C (vit C) as antioxidant. Exposure of rats to LTC during 3 weeks caused a significant (p < 0.05) increase in the levels of lipid peroxidation (LPO), nitric oxide (NO) and protein carbonyls (PCO) along with a significant (p < 0.05) decrease in the levels of reduced glutathione (GSH) and the activities of acetylcholinesterase, superoxide dismutase, catalase, glutathione peroxidase and gluthione-S-transferase (p < 0.05) when compared with the control group. The oral administration of vit C (200 mg/kg per d) to LTC-treated rats significantly (p < 0.05) diminished the levels of LPO, NO and PCO and significantly (p < 0.05) increased the activities of GSH and antioxidant enzymes. Our results showed that the administration of vit C could ameliorate some of the oxidative damage in the cerebellum induced by SPs exposure, suggesting that the ascorbic acid could exhibit a potential antioxidant activity against neurotoxicity induced by pesticides exposure.