Evaluation of endogenous fatty acid amides and their synthetic analogues as potential anti-inflammatory leads

…, J Hong, JS Choi, HS Kim, HY Chung, JH Jung

Index: Dang, Hung The; Kang, Gyeoung Jin; Yoo, Eun Sook; Hong, Jongki; Choi, Jae Sue; Kim, Hyung Sik; Chung, Hae Young; Jung, Jee H. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 4 p. 1520 - 1527

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Citation Number: 19

Abstract

A series of endogenous fatty acid amides and their analogues (1–78) were prepared, and their inhibitory effects on pro-inflammatory mediators (NO, IL-1β, IL-6, and TNF-α) in LPS- activated RAW264. 7 cells were evaluated. Their inhibitory activity on the pro-inflammatory chemokine MDC in IFN-γ-activated HaCaT cells was also examined. The results showed that the activity is strongly dependent on the nature of the fatty acid part of the molecules. ...