Molecular mechanisms of macrolide resistance in clinical isolates of Mycoplasma pneumoniae from China.

Deli Xin, Zuhuang Mi, Xu Han, Ling Qin, Jing Li, Tianli Wei, Xiaogeng Chen, Shaojie Ma, Ancun Hou, Gui Li, Dawei Shi

Index: Antimicrob. Agents Chemother. 53 , 2158-9, (2009)

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Abstract

Fifty clinical Mycoplasma pneumoniae strains were isolated from 370 children with respiratory tract infections. Four strains were susceptible to macrolides, while the other 46 (92%) were macrolide resistant. The molecular mechanism of resistance was shown to be associated with point mutations in 23S rRNA at positions 2063 and 2064.