Design, synthesis and evaluation of novel diaryl urea derivatives as potential antitumor agents
C Lu, K Tang, Y Li, P Li, Z Lin, D Yin, X Chen…
Index: Lu, Chenshu; Tang, Ke; Li, Yan; Li, Peng; Lin, Ziyun; Yin, Dali; Chen, Xiaoguang; Huang, Haihong European Journal of Medicinal Chemistry, 2014 , vol. 77, p. 351 - 360
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Citation Number: 5
Abstract
Abstract A novel series of diaryl ureas containing different linker groups were designed and synthesized. Their in vitro antitumor activity against MX-1, A375, HepG2, Ketr3 and HT-29 was evaluated using the standard MTT assay. Compounds having a rigid linker group such as vinyl, ethynyl and phenyl showed significant inhibitory activity against a variety of cancer cell lines. Specifically, compound 23 with a phenyl linker group demonstrated broad- ...
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