Synthesis and Properties of Optically Active Dispiro [2.0. 2.1] heptane Derivatives as Novel Ferroelectric Liquid Crystalline Compounds

…, DS Yufit, JAK Howard, A de Meijere

Index: Miyazawa; Yufit; Howard; De Meijere European Journal of Organic Chemistry, 2000 , # 24 p. 4109 - 4117

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Citation Number: 13

Abstract

Abstract Enantioselective enzymatic acylation, using Lipase PS®(Pseudomonas sp., immobilized on Celite, Amano Pharmaceutical Co., Ltd.), of endo-dihalosubstituted and nonsubstituted dispiro [2.0. 2.1] heptylmethanol and endo-4-methylenespiropentylmethanol provided the corresponding optically active compounds in high enantiomeric excesses (> 95% ee). Difluorocarbene addition onto the optically active endo-4- ...