Archives of Virology 1998-01-01

Effects of reducing, oxidizing and alkylating agents on early steps of Junin virus multiplication.

L J Raiger Iustman, V Castilla, V Meich, S E Mersich

Index: Arch. Virol. 143(7) , 1425-32, (1998)

Full Text: HTML

Abstract

The action of reducing, oxidizing and thiol-alkylating agents on early steps of Junin virus (JV) multiplication in Vero cells was investigated. The presence of reducing agents during virus adsorption as well as incubation of viral particles with these compounds before infection enhanced JV infectivity. On the contrary, the thiol-alkylating agent 5,5' dithiobis (2-nitrobenzoic acid) and the oxidizing compound potassium periodate showed an inhibitory effect, suggesting that sulfhydryl groups, and certain sugar moieties of viral glycoproteins play an important role in the first steps of JV infection. Also enzymatic treatment of cell monolayers and addition of concanavalin A to cultures prior to infection suggest that cellular glycoproteins are involved in virus attachment.

Related Compounds

Related Articles:

Various forms of rabbit plasma alpha-1-antiproteinase.

1998-09-01

[Biochem. Mol. Biol. Int. 46(1) , 27-34, (1998)]

Characterization of acid-induced molten globule like state of ficin.

2009-10-01

[Int. J. Biol. Macromol. 45(3) , 248-54, (2009)]

Variation in aspects of cysteine proteinase catalytic mechanism deduced by spectroscopic observation of dithioester intermediates, kinetic analysis and molecular dynamics simulations.

2001-07-15

[Biochem. J. 357(Pt 2) , 343-52, (2001)]

Production and characterization of two variants of human cystatin SA encoded by two alleles at the CST2 locus of the type 2 cystatin gene family.

1998-04-15

[Arch. Biochem. Biophys. 352(2) , 199-206, (1998)]

Persistence of cefotetan on red blood cells.

2004-06-01

[Transfusion 44(6) , 849-52, (2004)]

More Articles...