A new synthesis of Rink's polymer, 4-(2',4'-dimethoxyphenylhydroxymethyl)phenoxymethylpolystyrene .

G Váradi, G K Tóth, B Penke

Index: Int. J. Pept. Protein Res. 43(1) , 29-30, (1994)

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Abstract

For solid-phase peptide synthesis, 2,4-dimethoxy-4'-hydroxbenzhydrol linker was prepared via lithium borohydride reduction of 2,4-dimethoxy-4'-hydroxybenozophenone. The potassium salt of the linker was coupled to chloromethylpolystyrene. This method proved to be better than use of the cesium salt. This new synthesis gave a polymer with appropriate structure and a good degree of substitution.