Journal of medicinal chemistry

Synthesis and investigation of effects of 2-[4-[[(arylamino) carbonyl] amino] phenoxy]-2-methylpropionic acids on the affinity of hemoglobin for oxygen: structure-activity …

I Lalezari, P Lalezari

Index: Lalezari, Iraj; Lalezari, Parviz Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2352 - 2357

Full Text: HTML

Citation Number: 23

Abstract

LR-16 (8g4) was prepared by a multistep reaction starting from 4-nitropheno12 with an overall yield of 25-28%(see Scheme I). In view of the biological importance of this new class of compounds and the need for larger quantities and evaluation of the role of different substituents, we have found the three independent synthetic methods outlined in Schemes 11-IV. In these simplified methods (AC), the yields were ranged between 55 and 75%. In ...