Studies on condensed pyrimidine systems. XII. Synthesis of some 4-and 2, 4-substituted pyrido [2, 3-d] pyrimidines

RK Robins, GH Hitchings

Index: Robins; Hitchings Journal of the American Chemical Society, 1955 , vol. 77, p. 2256,2259

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Citation Number: 45

Abstract

2-Aminonicotinic acid reacts with formamide, urea and thiourea to yield 4-hpdroxy-(I), 2, 4- dihydroxy-(IX) and X-mercapto--i-hydroxy-(VI) pyrido [2, 3-d] pyrimidines, respectively. These substances serve as starting materials for transformation reactions leading to a variety of pyrido-[2, 3-d] pyrimidines with one or two functional groups in the pyrimidine moiety. Some similarities and differences between the pyrido [2, 3-d]-pyrimidines and ...