Detecting drug-induced prolongation of the QRS complex: New insights for cardiac safety assessment
C. Cros, M. Skinner, J. Moors, P. Lainee, J.P. Valentin
Index: Toxicol. Appl. Pharmacol. 265(2) , 200-8, (2012)
Full Text: HTML
Abstract
Background Drugs slowing the conduction of the cardiac action potential and prolonging QRS complex duration by blocking the sodium current (INa) may carry pro-arrhythmic risks. Due to the frequency-dependent block of INa, this study assesses whether activity-related spontaneous increases in heart rate (HR) occurring during standard dog telemetry studies can be used to optimise the detection of class I antiarrhythmic-induced QRS prolongation.
Related Compounds
Related Articles:
Multiple modes of ryanodine receptor 2 inhibition by flecainide.
2014-12-01
[Mol. Pharmacol. 86(6) , 696-706, (2014)]
Serum flecainide S/R ratio reflects the CYP2D6 genotype and changes in CYP2D6 activity.
2015-08-01
[Drug Metab. Pharmacokinet. 30 , 257-62, (2015)]
A misguided 'pill in the pocket' approach with flecainide leading to cardiac arrest.
2012-01-01
[BMJ Case Rep. 2012 , doi:10.1136/bcr-2012-006868, (2012)]
A case of near-fatal flecainide overdose in a neonate successfully treated with sodium bicarbonate.
2013-04-01
[J. Emerg. Med. 44(4) , 781-3, (2013)]
2013-06-01
[Clin. Toxicol. (Phila.) 51(5) , 394-7, (2013)]