Archives of Toxicology 2004-08-01

Short-term black tea intake modulates the excretion of urinary mutagens in rats treated with 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ): role of CYP1A2 upregulation.

V R Yoxall, D A Parker, P A Kentish, C Ioannides

Index: Arch. Toxicol. 78(8) , 477-82, (2004)

Full Text: HTML

Abstract

Rats were exposed to black tea (2.5% w/v) as their sole drinking liquid for either 1 day or 1 month, while controls were maintained on water. After this treatment period, all animals received a single oral dose IQ (2-amino-3-methylimidazo-[4,5-f]quinoline), and urine was collected for 48 h. Mutagenic activity of the urine was determined in the Ames test in the presence and absence of an activation system. The excretion of direct-acting mutagens was markedly reduced following tea intake, and was more pronounced after the 1-day treatment. Similarly, both tea treatments suppressed the excretion of indirect-acting mutagens. Furthermore, both tea treatments induced hepatic CYP1A2 activity and expression, but cytosolic glutathione S-transferase activity was only modestly induced in the group of animals receiving tea for 1 day, and only when DCNB (1,2-dichloro-4-nitrobenzene) was used as substrate; glucuronosyl activity was elevated modestly only in the animals receiving the tea for a month. It is concluded that even short-term exposure to black tea is capable of influencing the metabolic fate of IQ, and this is most likely related to the upregulation of CYP1A2.


Related Compounds

Related Articles:

Low glutathione S-transferase dogs.

2004-04-01

[Arch. Toxicol. 78(4) , 218-25, (2004)]

Mitogen-activated protein kinase p38b interaction with delta class glutathione transferases from the fruit fly, Drosophila melanogaster.

2012-01-01

[J. Insect Sci. 12 , 107, (2012)]

Glutathione conjugation of perchloroethene in subcellular fractions from rodent and human liver and kidney.

1998-11-06

[Chem. Biol. Interact. 116(1-2) , 31-43, (1998)]

Expression of the theta class GST isozyme, YdfYdf, in low GST dogs.

2006-05-01

[Arch. Toxicol. 80(5) , 250-7, (2006)]

Quantitative and qualitative gender-related differences in jejunal glutathione S-transferase in the rat effect of testosterone administration.

2000-12-15

[Life Sci. 68(4) , 467-74, (2000)]

More Articles...