"One-pot" syntheses of malondialdehyde adducts of nucleosides.
Jozsef Szekely, Hao Wang, Katherine M Peplowski, Charles G Knutson, Lawrence J Marnett, Carmelo J Rizzo
Index: Nucleosides Nucleotides Nucleic Acids 27(2) , 103-9, (2008)
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Abstract
Short, "one-pot" syntheses of malondialdehyde adducts of deoxyguanosine, deoxyadenosine, and deoxycytidine are described. These syntheses proceed in improved yield and easier purification than previous syntheses and are well suited for the preparation of isotopically labeled nucleoside adducts for biomarker and metabolic studies.
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