2, 4, 6??Trifluoropyrimidine. Reactions with nitrogen nucleophiles

…, DP Anderson, JM Schomaker

Index: Delia, Thomas J.; Anderson, Dennis P.; Schomaker, Jennifer M. Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 6 p. 991 - 993

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Citation Number: 5

Abstract

Abstract In a continuation of our studies involving the nucleophilic displacement of one of the chlorines from 2, 4, 6-trichloropyrimidine, we now report the initial displacement of one of the fluorine atoms from 2, 4, 6-trifluoropyrimidine using both aliphatic and aromatic amines. The monosubstitution products favor 2-substitution with ammonia and ethanolamine while aniline gave the 4-substituted derivative as the preferred product.