The Reaction of Certain Secondary Amines with Phthalic Anhydride. A New Synthesis of β-Alanine

S Chodroff, R Kapp, CO Beckmann

Index: Chodroff; Kapp; Beckmann Journal of the American Chemical Society, 1947 , vol. 69, p. 256

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Citation Number: 11

Abstract

Summary 1. N-Hydroxymethylphthalimide reacts with certain nitriles in concentrated sulfuric acid to yield the N-(phthalimido methyl) derivatives of the amides corresponding to the nitriles. It seems probable that the similar condensation of English and Clapp yielded a product analogous to those reported here. 3. N-Hydroxymethylphthalimide does not react with the active methylene group of malonic acid or ester in sulfuric acid solution.