Efficient and eco-friendly synthesis of iodinated aromatic building blocks promoted by iodine and hydrogen peroxide in water: a mechanistic investigation by mass …
…, GA Casagrande, L Pizzuti, D Oliveira-Silva…
Index: Gallo, Rafael D.C.; Ferreira, Irlon M.; Casagrande, Gleison A.; Pizzuti, Lucas; Oliveira-Silva, Diogo; Raminelli, Cristiano Tetrahedron Letters, 2012 , vol. 53, # 40 p. 5372 - 5375
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Citation Number: 9
Abstract
The reaction of aromatic and heteroaromatic compounds with molecular iodine in the presence of aqueous hydrogen peroxide using water without any co-solvent at 50° C for 24h produced versatile iodinated organic molecules with potential application in organic synthesis and medicine in very good yields. In addition, a mechanistic investigation for the iodination process was carried out by mass spectrometry.
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