American Journal of Psychiatry 1981-01-01

Synergism of combined lithium-neuroleptic therapy: a double-blind, placebo-controlled case study.

L B Bigelow, D R Weinberger, R J Wyatt

Index: Am. J. Psychiatry 138(1) , 81-3, (1981)

Full Text: HTML

Abstract

The authors describe a longitudinal, placebo-controlled study of the response to drug treatment of a 62-year-old schizoaffective patient hospitalized for 40 years. While neither lithium nor a neuroleptic drug alone was effective, both drugs administered simultaneously led to the gradual extinction of a pronounced behavioral cycle and the disappearance of manifest psychosis. The authors suggest a synergistic interaction between the two drugs and stress the need for sustained trials of the combination in patients with similar behavioral cycles.


Related Compounds

Related Articles:

[CLINICAL OBSERVATIONS ON THE ACTION OF TINDAL IN PSYCHIATRIC TREATMENT].

1964-01-01

[Neurol. Neurochir. Psychiatr. Pol. 14 , 683-6, (1964)]

HEMODYNAMIC EFFECTS OF IMIPRAMINE, ACETOPHENAZINE, AND TRIFLUOPERAZINE IN GERIATRIC PSYCHIATRY.

1965-07-01

[Dis. Nerv. Syst. 26 , 427-9, (1965)]

BEHAVIORAL IMPROVEMENT IN THE OLDER SCHIZOPHRENIC PATIENT: DRUG AND SOCIAL THERAPIES.

1965-01-01

[J. Am. Geriatr. Soc. 13 , 57-72, (1965)]

CHEMOTHERAPY FOR EMOTIONALLY DISTURBED CHILDREN: A FOLLOW-UP REPORT.

1964-12-01

[Dis. Nerv. Syst. 25 , 735-8, (1964)]

OBSERVATIONS ON ACETOPHENAZINE.

1964-10-01

[Am. J. Psychiatry 121 , 387-8, (1964)]

More Articles...