Cancer Science 2011-12-01

Antitumor effects of α-bisabolol against pancreatic cancer.

Takashi Seki, Toshio Kokuryo, Yukihiro Yokoyama, Hisanori Suzuki, Keita Itatsu, Akifumi Nakagawa, Tetsushi Mizutani, Takashi Miyake, Masanori Uno, Kohei Yamauchi, Masato Nagino

Index: Cancer Sci. 102(12) , 2199-205, (2011)

Full Text: HTML

Abstract

In the present study, we investigated whether α-bisabolol, a sesquiterpene alcohol present in essential oils derived from a variety of plants, has antitumor effects against pancreatic cancer. α-Bisabolol induced a decrease in cell proliferation and viability in pancreatic cancer cell lines (KLM1, KP4, Panc1, MIA Paca2), but not in pancreatic epithelial cells (ACBRI515). α-Bisabolol treatment induced apoptosis and suppressed Akt activation in pancreatic cancer cell lines. Furthermore, α-bisabolol treatment induced the overexpression of early growth response-1 (EGR1), whereas EGR1 siRNA decreased the α-bisabolol-induced cell death of KLM1 cells. Tumor growth in both subcutaneous and peritoneal xenograft nude mouse models was significantly inhibited by intragastric administration of 1000 mg/kg of α-bisabolol, once a week for three weeks. The results indicate that α-bisabolol could be a novel therapeutic option for the treatment of pancreatic cancer.© 2011 Japanese Cancer Association.


Related Compounds

Related Articles:

The antimicrobial activity of alpha-bisabolol and tea tree oil against Solobacterium moorei, a Gram-positive bacterium associated with halitosis.

2013-01-01

[Arch. Oral Biol. 58(1) , 10-6, (2013)]

In vitro and in vivo antimalarial activity of essential oils and chemical components from three medicinal plants found in northeastern Brazil.

2012-05-01

[Planta Med. 78(7) , 658-64, (2012)]

Evaluation of the mutagenicity of sesquiterpenic compounds and their influence on the susceptibility towards antibiotics of two clinically relevant bacterial strains.

2011-07-14

[Mutat. Res. 723(1) , 18-25, (2011)]

Enantioselective microbial synthesis of the indigenous natural product (-)-α-bisabolol by a sesquiterpene synthase from chamomile (Matricaria recutita).

2014-10-15

[Biochem. J. 463(2) , 239-48, (2014)]

Anti-nociceptive and anti-inflammatory activities of (-)-α-bisabolol in rodents.

2011-12-01

[Naunyn Schmiedebergs Arch. Pharmacol. 384(6) , 525-33, (2011)]

More Articles...