Design, synthesis and structure–activity relationships of 3, 5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase
E Fullam, J Talbot, A Abuhammed, I Westwood…
Index: Fullam, Elizabeth; Talbot, James; Abuhammed, Areej; Westwood, Isaac; Davies, Stephen G.; Russell, Angela J.; Sim, Edith Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2759 - 2764
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Citation Number: 11
Abstract
The synthesis and inhibitory potencies of a novel series of 3, 5-diaryl-1H-pyrazoles as specific inhibitors of prokaryotic arylamine N-acetyltransferase enzymes is described. The series is based on hit compound 1 3, 5-diaryl-1H-pyrazole identified from a high-throughout screen that has been carried out previously and found to inhibit the growth of Mycobacterium tuberculosis.
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