Pharmazie 2002-08-01

[Reactions between dialkylamine drugs, 2,3-dichloro-1,4-naphthoquinone and acetaldehyde].

H J Kallmayer, B Thierfelder

Index: Pharmazie 57(8) , 530-4, (2002)

Full Text: HTML

Abstract

Dialkylamine drugs desipramine, propanolol, pindolol, alprenolol and metoprolol 4a-e react with 2,3-dichloro-1,4-naphthoquinone (2) and acetaldehyde to give red coloured 2-dialkylamino-3-chloro-1,4-naphthoquinones 5a, b, d, e, blue coloured 2-dialkylamino-vinyl-3-chloro-1,4-naphtho-quinones 1a-e and bluish green coloured 2-dialkylamino-butadienyl-3-chloro-1,4-naphthoquinones 6b-e. The colour products are isolated by column chromatography.

Related Compounds

Related Articles:

Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.

2008-03-27

[J. Med. Chem. 51 , 1706-18, (2008)]

The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors.

2007-08-01

[Bioorg. Med. Chem. 15 , 5340-50, (2007)]

Modulation of hepatic cytochrome P-450 and DT-diaphorase by oral and sub-cutaneous administration of the pro-oxidant fungicide dichlone (2,3-dichloro-1,4-naphthoquinone).

1988-08-01

[Bull. Environ. Contam. Toxicol. 41(2) , 164-71, (1988)]

Spectroscopic and theoretical studies on the nucleophilic substitution of 2,3-dichloronaphthoquinone with para-substituted anilines in solid state via initial charge transfer complexation.

2012-12-01

[Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 98 , 378-83, (2012)]

Study of a reaction between 2,3-dichloro-1,4-naphthoquinone and N,N'-diphenyl thiourea involving an EDA adduct as intermediate.

1993-01-01

[Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 60(7) , 1641-7, (2004)]

More Articles...