The Journal of Organic Chemistry

Synthesis and properties of carbamate derivatives of tetrakis (hydroxymethyl) phosphonium chloride

AW Frank, GL Drake Jr

Index: Frank,A.W.; Drake,G.L. Journal of Organic Chemistry, 1977 , vol. 42, # 25 p. 4040 - 4045

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Citation Number: 9

Abstract

Tetrakis (hydroxymethy1) phosphonium chloride (1) condenses with primary or secondary alkyl carbamates, forming stable quaternary phosphonium salts having the structure (ROzCNHCH2) dPCl (3) or [EtOzCN (R)-CH214PCl (6). The alkyl carbamates are too feebly basic to cause the displacement of formaldehyde and HC1 that characterizes the reaction of 1 with primary or secondary amines. The quaternary phosphonium salt 3a (R= Me) ...