Palladium-catalyzed, one-pot, three-component synthesis of homoallylic amines from aldehydes, anisidine, and allyl trifluoroacetate
RE Grote, ER Jarvo
Index: Grote, Robin E.; Jarvo, Elizabeth R. Organic Letters, 2009 , vol. 11, # 2 p. 485 - 488
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Citation Number: 19
Abstract
An allylation reaction that generates homoallylic amines using allyl trifluoroacetate as a nucleophilic allylmetal precursor is reported. A palladium complex catalyzes two transformations in one pot: formation of allylsilane from allyl trifluoroacetate using hexamethyldisilane and subsequent imine allylation. A three-component reaction was developed where preformed imines were replaced with aldehydes and anisidine. Under ...
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