Organic Letters 2013-09-06

In(III)/PhCO2H binary acid catalyzed tandem [2 + 2] cycloaddition and Nazarov reaction between alkynes and acetals.

Lihui Zhu, Zhi-Guo Xi, Jian Lv, Sanzhong Luo

Index: Org. Lett. 15(17) , 4496-9, (2013)

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Abstract

A facile tandem [2 + 2] cycloaddition and Nazarov reaction has been developed. The combination of In(OTf)3 and benzoic acid was found to synergistically promote the coupling of alkynes and acetals to form 2,3-disubstituted indanones in excellent yield and diastereoselectivity.


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