Sodium Bis (trimethylsilyl) amide in the

…, CH Hsu, FF Wong, CS Chung, GH Hakimelahi

Index: Hwu, Jih Ru; Hsu, Chia Hao; Wong, Fong Fuh; Chung, Chung-Sun; Hakimelahi, Gholam H. Synthesis, 1998 , # 3 p. 329 - 332

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Citation Number: 13

Abstract

Organic nitriles are traditionally synthesized from the cor- responding carboxylic acids by ultimate dehydration of the corresponding amide intermediates.3 The transforma- tions consist of two steps or more, and isolation of inter- mediates is required. Several “one-flask” methods have been reported for the conversion of carboxylic acids to ni- triles.4–6 Acyl chlorides can also be converted to nitriles by sulfonamide in a “one-flask” reaction.7 To the best of our ...