Solubilisation of griseofulvin in aqueous micellar solutions of diblock copolymers of ethylene oxide and 1,2-butylene oxide with lengthy B-blocks

Maria Elenir N.P. Ribeiro, Igor Marques Cavalcante, Nágila M.P.S. Ricardo, Shao-Min Mai, David Attwood, Stephen G. Yeates, Colin Booth, Maria Elenir N.P. Ribeiro, Igor Marques Cavalcante, Nágila M.P.S. Ricardo, Shao-Min Mai, David Attwood, Stephen G. Yeates, Colin Booth

Index: Int. J. Pharm. 369(1-2) , 196-8, (2009)

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Abstract

The influence of hydrophobic-block length on solubilisation capacity was examined for micelles of E m B n copolymers (E = oxyethylene, B = oxybutylene, subscripts denote number-average block lengths in repeat units) with B-block lengths in the range of 30–76 and with E-blocks of sufficient length to ensure the formation of spherical micelles. Griseofulvin was used as a model poorly-water-soluble drug known to be almost exclusively solubilised in the micellar core. Combination of solubilisation data with those of a previous study has shown that the amount of drug solubilised per gram of hydrophobe is essentially independent of B-block length when this exceeds about 15 B units, suggesting that core size is not a major influence on solubilisation.