Hydrolysis in the absence of bulk water 1. Chemoselective hydrolysis of amides using tetrahalophthalic anhydrides

JT Eaton, WD Rounds, JH Urbanowicz, GW Gribble

Index: Eaton, Jefferson T.; Rounds, William D.; Urbanowicz, John H.; Gribble, Gordon W. Tetrahedron Letters, 1988 , vol. 29, # 50 p. 6553 - 6556

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Citation Number: 16

Abstract

Abstract The reaction of primary and secondary amides with tetrafluorophthalic or tetrachlorophthalic anhydride gives carboxylic acids in good yield. The reaction is chemoselective in that the amide functionality can be hydrolyzed in the presence of ester groups.