Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5, 8, 11, 13-tetraenoic acid analogs

F Haviv, JD Ratajczyk, RW DeNet…

Index: Haviv; Ratajczyk; DeNet; Martin; Dyer; Carter Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 254 - 263

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Citation Number: 22

Abstract

51 a (i) Catecholborane, THF;(ii) Pd (PPh3),, THF, 1 N NaOH. acids with soybean lipoxygenase, followed by sodium borohydride reduction and chromatographic purification.'5-HETE (56) was similarly converted to 5, 15-diHETE (58). The 15-HETE derivatives 4-6 were prepd. by using conventional methods. 5, 15-DiHETE easily cyclized to the &lactone 59 upon heating under reflux in benzene in the presence of p- ...