Antimicrobial Agents and Chemotherapy 2007-05-01

A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole.

Shaoji Cheng, Cornelius J Clancy, Katherine T Nguyen, William Clapp, M Hong Nguyen

Index: Antimicrob. Agents Chemother. 51 , 1855-8, (2007)

Full Text: HTML

Abstract

We showed that a Candida albicans petite mutant in which oxidative phosphorylation is uncoupled was eightfold more resistant to fluconazole and voriconazole than SC5314 but equally susceptible to ketoconazole, itraconazole, and amphotericin B. Strain P5 significantly overexpressed MDR1, which likely accounts for the decreased drug susceptibility.

Related Compounds

Related Articles:

Mycobacterial membrane vesicles administered systemically in mice induce a protective immune response to surface compartments of Mycobacterium tuberculosis.

2014-01-01

[MBio 5(5) , e01921-14, (2014)]

Modified vaccinia virus Ankara-infected dendritic cells present CD4+ T-cell epitopes by endogenous major histocompatibility complex class II presentation pathways.

2015-03-01

[J. Virol. 89(5) , 2698-709, (2015)]

Effector CD8+ T cells are generated in response to an immunodominant epitope in type III effector YopE during primary Yersinia pseudotuberculosis infection.

2014-07-01

[Infect. Immun. 82(7) , 3033-44, (2014)]

Diminished viral control during simian immunodeficiency virus infection is associated with aberrant PD-1hi CD4 T cell enrichment in the lymphoid follicles of the rectal mucosa.

2014-11-01

[J. Immunol. 193(9) , 4527-36, (2014)]

Methanolic extract of Origanum vulgare ameliorates type 1 diabetes through antioxidant, anti-inflammatory and anti-apoptotic activity.

2015-03-14

[Br. J. Nutr. 113(5) , 770-82, (2015)]

More Articles...