Regioselective synthesis of 1,3,5-substituted benzenes via the InCl(3)/2-iodophenol-catalyzed cyclotrimerization of alkynes.

Yan-li Xu, Ying-ming Pan, Qiang Wu, Heng-shan Wang, Pei-zhen Liu

Index: J. Org. Chem. 76(20) , 8472-6, (2011)

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Abstract

A novel indium(III)-catalyzed cyclotrimerization of alkynes in the presence of 2-iodophenol gave 1,3,5-substituted benzenes in excellent yields with complete regioselectivity. The reaction condition is tolerant to air, and atom economical, in accordance with the concept of modern green chemistry. This method provides a rapid and efficient access to 1,3,5-substituted benzenes.