Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa.
Hisashi Matsuda, Kazutoshi Yoshida, Katsutoshi Miyagawa, Yasunobu Asao, Saya Takayama, Souichi Nakashima, Fengming Xu, Masayuki Yoshikawa
Index: Bioorg. Med. Chem. 15 , 1539-46, (2007)
Full Text: HTML
Abstract
Principal rotenoids (deguelin, tephrosin, rotenone, and 12a-hydroxyrotenone) (3-30microM) isolated from the stems of Erycibe expansa significantly inhibited invasion of human fibrosarcoma HT1080 cells through Matrigel-coated filters and release of proMMPs-2 and 9. In addition, deguelin and tephrosin showed differentiation-inducing activity in human promyelocytic leukemia HL-60 cells. Furthermore, effects of various constituents isolated from the ethyl acetate-soluble fraction on proliferation of human leukemia U937 cells were examined. As a result, most of isoflavones and several flavans as well as rotenoids showed moderate or substantial anti-proliferative activities.
Related Compounds
Related Articles:
[Rotenoids from Derris trifoliata].
2007-06-01
[Zhong Yao Cai 30(6) , 660-2, (2007)]
2008-01-18
[J. Chromatogr. A. 1178(1-2) , 101-7, (2008)]
Effect of rotenoids from the seeds of Millettia dura on larvae of Aedes aegypti.
2003-10-01
[Pest Manag. Sci. 59(10) , 1159-61, (2003)]
Cytotoxic compounds from Mundulea chapelieri from the Madagascar Rainforest.
2004-03-01
[J. Nat. Prod. 67(3) , 454-6, (2004)]
2008-10-01
[J. Nat. Prod. 71(10) , 1696-700, (2008)]