Anti-inflammatory principles from Cordyceps sinensis.
Mei-Lin Yang, Ping-Chung Kuo, Tsong-Long Hwang, Tian-Shung Wu
Index: J. Nat. Prod. 74 , 1996-2000, (2011)
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Abstract
In order to explore the anti-inflammatory principles of the mycelia of Cordyceps sinensis, the crude extract and partially purified fractions were examined for their inhibition of superoxide anion generation and elastase release. Further chemical investigation of the bioactive fractions has resulted in the identification of 50 compounds, including five constituents, cordysinins A-E (1-5), reported from a natural source for the first time. In addition, compounds were examined for their anti-inflammatory activity. 1-(5-Hydroxymethyl-2-furyl)-β-carboline displayed the most significant inhibition of superoxide anion generation and elastase release with IC50 values of 0.45±0.15 and 1.68±0.32 μM, respectively.
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