Enantioselective sequential conjugate addition-allylation reactions: a concise total synthesis of (+)-podophyllotoxin.
Yingming Wu, Jingfeng Zhao, Jingbo Chen, Chengxue Pan, Liang Li, Hongbin Zhang
Index: Org. Lett. 11(3) , 597-600, (2009)
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Abstract
A highly flexible and concise total synthesis of (+)-podophyllotoxin featured with an enantioselective sequential conjugate addition-allylation reaction was reported. Starting from commercially available 3,4,5-trimethoxycinnamic acid, this new route leads to (+)-podophyllotoxin 1 in only eight steps with 29% overall yield.
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