N6-[2-(3, 5-dimethoxyphenyl)-2-(2-methylphenyl) ethyl] adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity …

AJ Bridges, RF Bruns, DF Ortwine…

Index: Bridges, Alexander J.; Bruns, Robert F.; Ortwine, Daniel F.; Priebe, Steven R.; Szotek, Deedee L.; Trivedi, Bharat K. Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1282 - 1285

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Citation Number: 100

Abstract

OH OH ceptor subtypes can be determined by using specific A, and A, receptor binding assay^.^ Many potent and selective A, agonists have been found, typified by R-PIA (1) 5 and CPA (2) 6 (Table I and Chart I). However, progress toward potent and selective A, agonists has been much slower. For instance, NECA (3): although very potent at A2 receptors: is slightly A, selective in the Al and A, binding assay^.^ Among the few known A,-selective ...