Copper-catalyzed synthesis of internal alkynes via domino coupling between 1, 1-dihalo-1-alkenes and arylboronic acids
H Yan, L Lu, P Sun, Y Zhu, H Yang, D Liu, G Rong…
Index: Yan, Hong; Lu, Linhua; Sun, Peng; Zhu, Yan; Yang, Hailong; Liu, Defu; Rong, Guangwei; Mao, Jincheng RSC Advances, 2013 , vol. 3, # 2 p. 377 - 381
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Citation Number: 5
Abstract
It is well known that structural motifs with carbon–carbon triple bonds have prevailed in many bioactive compounds, natural products, pharmaceuticals, and functional materials. 1 Since the late 20th century, the Sonogashira reaction has been proved to be an effective approach for the synthesis of various alkynes. 2 The typical Sonogashira coupling is performed in the presence of PdCl 2 (PPh 3 ) 2 or Pd(PPh 3 ) 4 together with CuI as the cocatalyst and larger amount ...
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