Synthetic approaches to bridgehead nitrogen methanesulfonamide derivatives of 3??amino??2??thioxo??2, 3??dihydrothieno [2, 3??d] pyrimidin??4 (1H)??ones, potential cox?? …

…, S Barbagallo, A Perdicaro, A Marrazzo…

Index: Granata, Giuseppe; Barbagallo, Salvatore; Perdicaro, Antonio; Marrazzo, Agostino; Santagati, Andrea; Lombardo, Laura; Cardile, Venera Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 4 p. 1099 - 1104

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Citation Number: 5

Abstract

For many years we have focused our interests in the synthesis of thienopyrimidine derivatives in order to find compounds endowed with anti-inflammatory and analgesic activity and no or low ulcerogenic activity [1, 2]. On the basis of recent developments in the research of non-steroidal anti-inflammatory drugs (NSAIDs) without ulcerogenic effects, acting as selective inhibitors of enzyme COX-2 [3, 4], we have synthesized new ...