Synthesis of pyrimidine derivatives by the reaction of ketene dithioacetals with amides

S Kohra, Y Tominaga, A Hosomi

Index: Kohra, Shinya; Tominaga, Yoshinori; Hosomi, Akira Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 959 - 968

Full Text: HTML

Citation Number: 38

Abstract

Abstract Reactions of methyl 2-cyano-3, 3-bis (methylthio) acrylate (1a) with carboxamides 2a-g in the presence of sodium hydride in a mixture of benzene and N, N-dimethylacetamide took place displacement with the methylthio group to give the corresponding methyl 3-N- acylamino-2-cyano-3-(methylthio) acrylates 3a-g which were readily converted to the corresponding pyrimidine derivatives at reflux in methanol in good yields. Reactions of 2- ...